Lipscomb County Sheriff James Robertson said in a news release Tuesday that the men were killed shortly after the blast in a remote part of the region.
Three people were injured. One was taken by helicopter to a hospital in Oklahoma City. Two others working near the explosion had injuries not considered life-threatening.
The five men were moving clay from a pit near the pipeline when a bulldozer struck it, causing the explosion.
The blast about 270 miles northeast of Lubbock is the second natural gas line explosion in Texas in as many days.
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