Fire officials say the blaze in the city's Silver Lake section was reported at about 10 p.m. on Wednesday.
The victim, a 41-year-old man, was found inside the building. His name was not immediately made public.
Three neighbors who desperately tried to save the victim by removing a door from its hinges were treated for smoke inhalation but are expected to survive.
Neighbor Shawn Leonard tells WPRI-TV that he heard an explosion before running outside to try and help the victim.
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